![]() In addition to high protein expression level, high solubility is preferable for the purification and long-term storage of recombinant proteins. Accessibility is computed by considering all possible structures for a region, weighted by free energy, not just the single structure with the MFE ( 28). However, more recent work shows that the mRNA accessibility of translation initiation sites outperforms MFE in predicting relative protein levels from mRNA sequences ( 26, 27). Recent systematic studies suggest that MFE is the most important feature in protein expression ( 24, 25). This, in turn, hinders the development of accurate prediction/optimisation tools. Many of these features are not independent, making it challenging to distinguish the impacts of individual features ( 24). These features are mostly related to codon usage, such as the codon adaptation index and tRNA adaptation index ( 13–17), or measures of mRNA secondary structure, such as G+C content, minimum free energy (MFE) of RNA secondary structure, and mRNA:ncRNA interaction avoidance ( 18–23). Since mRNA abundance alone is insufficient to explain protein abundance ( 8–12), several features of mRNA sequence have been proposed to affect protein expression. However, low protein expression and aggregation are the two major bottlenecks of recombinant protein production ( 1–7). In addition to base pay, certain roles are eligible to participate in our bonus or commission plans, as well as our benefits offerings, and equity awards.Recombinant protein production is a key process for life science research and the development of biotherapeutics. ![]() Compensation varies based on a variety of factors which include (but aren’t limited to) such as role level, skills and competencies, qualifications, knowledge, location, and experience. The expected annual base salary range for this position is $61,100.00 - $68,150.00. Only Sumo Logic delivers its platform as a true, multi-tenant SaaS architecture, across multiple use-cases, enabling businesses to thrive in the Intelligence Economy. More than 2,100 customers rely on Sumo Logic to build, run, and secure their modern applications and cloud infrastructures. The Sumo Logic Continuous Intelligence Platform™ automates the collection, ingestion, and analysis of application, infrastructure, security, and IoT data to derive actionable insights within seconds. ![]() Sumo Logic is the pioneer in continuous intelligence, a new category of software, which enables organizations of all sizes to address the data challenges and opportunities presented by digital transformation, modern applications, and cloud computing.
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